Yes it is. You won't figure out everything by planning, but everything you do saves you trouble in the end. I will let you know how it does. I have one installed in my Safari with a pretty similar setup. It is smaller but exhausts the same way. The one in the E350 is a bit bigger. The flange size is larger as well. You can't see it in the picture, but the bolts extend about an inch below the flange. I will use the extra thread to attach a screen. <br><br>There were two issues I had with the portable ac installed in the Safari. The first was that the exhaust hose gets pretty warm. This actually adds some heat as you are cooling. I will be using an insulated hose this time around. Should pretty much eliminate that problem. <br><br>The second issue is that it draws air from the vehicle to cool the coils and then exhausts it through the hose. On the Safari, that meant it used some of the air it had just cooled for the coils. There was no way to really address this in the Safari. It wasn't a big deal because the van was so small. It still cooled really well. On this van I will address that somewhat. The air conditioner is in a space built into the cabinet. It will draw air for its coils from inside the cabinet space. This space is open along the whole passenger side of the van. That means it will effectively be drawing air from under the bed and where the camping potty stores. The cool air will blow out into the cabin. This should keep the two air spaces fairly well separated.<br><br>Will let you know how it works out.