It depends on how well the van was maintained by the previous owner, whether you are trying to play "catch up", or if you are planning on doing regularly scheduled maintenance.
If playing catch-up, I would look at replacing all fluids, including rear differential, transmission, coolant, brake fluid, engine oil, and power steering. I would also replace old belts, and hoses (it's tough to tell how old, and brittle they are).
It it hasn't been done yet, replace your spark plugs also, there is no need for new plug wires on a 2010 Ford, they have coil packs on top of the plugs.
While doing the fluids, replace your filters also, fuel, oil, air, PCV, cabin air, transmission.
This will get you motor/drivetrain in tip top shape, but there is still brakes, shocks, tires, and other wearable items that will need replaced periodically.
Tires all have a date code imprinted on the side of them that shows the date they were built. You shouldn't run tires past 5-6 years regardless of how much tread they have. Running highway speeds hours on end, on a 90* day will start making old/cracked tires come apart.