In my experience Ford's fuel systems have always been a pain in the butt.
My 90 E 350 Hiigh top Van gave me problems with the single 22 gallon tank. I purchased a new in the tank fuel pump assembly (tiny pump) and it lasted about a year.
So I spoke with a friend who had a business with some F 250 Pickup's that had dual tanks. He had had nothing but problems with the factory system. Even a couple of years ago a new member joined this forum and had a Class C built on the Ford platform and was having troubles with the same.
My friend with the business explained that they solved the problem and had me talk with his shop mechanic who explained how they put external (generic) pumps on both tanks and skipped the maddening automatic valve which switched tanks as one neared empty.
The mechanic told me that they left the original tank pump assembly in the tank and the external pumps just drew trough them and supplied the high pressure fuel system pump better than those factory tank pumps ever could and the trucks would run better than when new.
I paid about $12 bucks for a universal pump and spliced in to the wires that went to the tank pump. A visit to the junk yard got me some tubing from a wreck to adapt the pump such that my install was easier. (no leaks) The pump was loud as I had it bolted to the frame ahead of the tank....so I found some rubber material and loosened the clamp to mount the pump in that rubber. Problem solved. Now when I turn the key on I hear both pumps come up and go quiet. Barely hear either of them once started and running.
I don't know if you have the system that automatically switches one tank to the other or the switch system with two gasoline gauges like some. But that automatic switch is a nightmare for anyone who has ever had one and had to deal with it jamming and neither tank supplying fuel.
This is the pump I installed in mine. And photo below, the pump my friend used on his F 250's. (which could pump higher volumes of fuel to the high pressure pump which supplied the fuel injectors)
My E 350 Van has better take off now than ever before.
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