Hi, Chance,
I think you've asked a very broad question that would be a bit complicated to answer. I know some folks on the forum have mentioned having made a few east coast to west coast trips.
I think you'd have to narrow it down by which season you'd be traveling in. For instance, I-40's general route has the Grand Canyon (and lots of boondocking in the forests arouand Flagstaff). But you may not want to go there is you are traveling in January. I-10 would likely be more comfy and safe.
There's a current thread on here about a road trip following the old Route 66. Very fun and quirky small towns and photos of museums and retro signs. See Route 66 Roadtrip.
My favorite state for warm months is Montana, and I am fond of Hwy 12 going east to west (though, yes, the eastern part is a LOT of high plains).
I tend not to take as many photos as I used to. Instead taking "heart photos" - but many on here do landscape photography as a hobby.